first-line first trends in thiazide prescribing for hypertensive seniors一线的第一个趋势噻嗪类处方为高血压的老年人.pdfVIP

Open access, freely available online PLoS MEDICINE First-Line First? Trends in Thiazide Prescribing for Hypertensive Seniors 1* 1 2 1 Steve Morgan , Kenneth L. Bassett , James M. Wright , Lixiang Yan 1 Centre for Health Services and Policy Research, University of British Columbia, Vancouver, Canada, 2 Pharmacology and Therapeutics Department, University of British Columbia, Vancouver, Canada Competing Interests: The authors A B S T R A C T have declared that no competing interests exist. Background Author Contributions: SM, KB, and JW designed the study. SM and LY Evidence of reduced cardiovascular morbidity and mortality as well as cost support thiazide analyzed the data. All authors contributed to writing the paper. diuretics as the first-line choice for treatment of hypertension. The purpose of this study was to determine the proportion of senior hypertensives that received thiazide diuretics as first-line Academic Editor: Anthony Keech, treatment, and to determine if cardiovascular and other potentially relevant comorbidities University of Sydney, Australia predict the choice of first-line therapy. Citation: Morgan S, Bassett KL, Wright JM, Yan L (2005) First-line Methods and Findings first? Trends in thiazide prescrib- ing for hypertensive seniors. PLoS Med 2(4): e80. British Columbia PharmaCare data were used to determine the cohort of seniors (residents aged 65 or older) who received their first reimbursed hypertension drug during the period 1993 Received: July 20, 2004 to 200