first isolation of hepatitis e virus genotype 4 in europe through swine surveillance in the netherlands and belgium在欧洲第一隔离e型肝炎病毒基因型4通过猪监测在荷兰和比利时.pdfVIP

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first isolation of hepatitis e virus genotype 4 in europe through swine surveillance in the netherlands and belgium在欧洲第一隔离e型肝炎病毒基因型4通过猪监测在荷兰和比利时.pdf

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first isolation of hepatitis e virus genotype 4 in europe through swine surveillance in the netherlands and belgium在欧洲第一隔离e型肝炎病毒基因型4通过猪监测在荷兰和比利时

First Isolation of Hepatitis E Virus Genotype 4 in Europe through Swine Surveillance in the Netherlands and Belgium 1 2 1 1,3 Renate W. Hakze-van der Honing , Els van Coillie , Adriaan F. G. Antonis , Wim H. M. van der Poel * 1 Wageningen University and Research Centre, Lelystad, The Netherlands, 2 Institute for Agricultural and Fisheries Research (ILVO), Melle, Belgium, 3 University of Liverpool, Liverpool, United Kingdom Abstract Hepatitis E virus (HEV) genotypes 3 and 4 are a cause of human hepatitis and swine are considered the main reservoir. To study the HEV prevalence and characterize circulating HEV strains, fecal samples from swine in the Netherlands and Belgium were tested by RT-PCR. HEV prevalence in swine was 7–15%. The Dutch strains were characterized as genotype 3, subgroups 3a, 3c and 3f, closely related to sequences found in humans and swine earlier. The HEV strains found in Belgium belonged to genotypes 3f and 4b. The HEV genotype 4 strain was the first ever reported in swine in Europe and an experimental infection in pigs was performed to isolate the virus. The genotype 4 strain readily infected piglets and caused fever and virus shedding. Since HEV4 infections have been reported to run a more severe clinical course in humans this observation may have public health implications. Citation: Hakze-van der Honing RW, van Coillie E, Antonis AFG, van der Poel WHM (2011) First Isolation of Hepatitis E Virus Genotype 4 in Europe through Swine Surveillance in the Netherlands and Belgium. PLoS ONE 6(8): e22673. doi:10.1371/journal.pone.0022673 Editor: Tara C. Smith, University of Iowa, United Sta