g protein subunit dissociation and translocation regulate cellular response to receptor stimulationg蛋白亚基解离和易位对受体刺激调节细胞反应.pdfVIP
- 1、本文档共11页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
g protein subunit dissociation and translocation regulate cellular response to receptor stimulationg蛋白亚基解离和易位对受体刺激调节细胞反应
G Protein Subunit Dissociation and Translocation
Regulate Cellular Response to Receptor Stimulation
1 1 1 1 1,2
Mariangela Chisari , Deepak Kumar Saini , Joon-Ho Cho , Vani Kalyanaraman , N. Gautam *
1 Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, United States of America, 2 Department of Genetics, Washington
University School of Medicine, St. Louis, Missouri, United States of America
Abstract
We examined the role of G proteins in modulating the response of living cells to receptor activation. The response of an
effector, phospholipase C-b to M3 muscarinic receptor activation was measured using sensors that detect the generation
of inositol triphosphate or diacylglycerol. The recently discovered translocation of Gbc from plasma membrane to
endomembranes on receptor activation attenuated this response. A FRET based G protein sensor suggested that in contrast
to translocating Gbc, non-translocating Gbc subunits do not dissociate from the aq subunit on receptor activation leading
to prolonged retention of the heterotrimer state and an accentuated response. M3 receptors with tethered aq induced
differential responses to receptor activation in cells with or without an endogenous translocation capable c subunit. G
protein heterotrimer dissociation and bc translocation are thus unanticipated modulators of the intensity of a cell’s
response to an extracellular signal.
Citation: Chisari M, Saini DK, Cho J-H, Kalyanaraman V, Gautam N (2009) G Protein Subunit Dissociation and Translocation Regulate Cellular Response to
Re
您可能关注的文档
- fitness trade-offs in the evolution of dihydrofolate reductase and drug resistance in plasmodium falciparum健身权衡二氢叶酸还原酶的进化和恶性疟原虫的耐药性.pdf
- fitness landscape transformation through a single amino acid change in the rho terminator健身景观转换通过单个氨基酸的变化ρ终结者.pdf
- fitting the elementary rate constants of the p-gp transporter network in the hmdr1-mdck confluent cell monolayer using a particle swarm algorithm拟合的基本速率常数p-gp运输网络hmdr1-mdck汇合的细胞单层使用粒子群算法.pdf
- fish oil enhances recovery of intestinal microbiota and epithelial integrity in chronic rejection of intestinal transplant鱼油增强肠道菌群与上皮完整性恢复肠道慢性排斥反应的移植.pdf
- five futures for academic medicine五个学术医学期货.pdf
- fitness of mycobacterium tuberculosis strains of the w-beijing and non-w-beijing genotype健身的结核分枝杆菌菌株w-beijing non-w-beijing基因型.pdf
- five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls meta-analysis of 130 studies五个谷胱甘肽s-transferase基因变异在23452例肺癌和23452年控制130个研究的荟萃分析.pdf
- five mechanisms of manipulation by bacterial effectors a ubiquitous theme五个机制的操纵细菌效应器无处不在的主题.pdf
- fishing for prion protein function钓朊蛋白的功能.pdf
- five myths about the hiv epidemic in asia亚洲艾滋病流行的五大神话.pdf
- 分析let s单元56ago2卷纸zheng unit56.pdf
- 塑胶材料其它分类原料pa9t 12.pdf
- md16x16数字媒体切换器设备.pdf
- 者参考项目发起人学科类型单位序列承包商修订页代码顺序典型.pdf
- 届世界天然气大会阿姆斯特丹2006add10288.pdf
- 期测试记录表每周weekly g1g6 journeys tests level 6 lesson26.pdf
- modernize-whitepaper现代化您应用程序白皮书.pdf
- anybackup产品典型案例分析.pdf
- 约克金融工程课程tfeslide32.pdf
- 广州市妇女儿童医疗中心历份教学药历01tjy.pdf
文档评论(0)