genetic manipulation of palmitoylethanolamide production and inactivation in saccharomyces cerevisiae在酿酒酵母基因操纵palmitoylethanolamide生产和失活.pdfVIP
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genetic manipulation of palmitoylethanolamide production and inactivation in saccharomyces cerevisiae在酿酒酵母基因操纵palmitoylethanolamide生产和失活
Genetic Manipulation of Palmitoylethanolamide
Production and Inactivation in Saccharomyces cerevisiae
1,2 3 3 1,4
Giulio G. Muccioli , Angela Sia , Paul J. Muchowski *, Nephi Stella *
1 Department of Pharmacology, University of Washington, Seattle, Washington, United States of America, 2 Louvain Drug Research Institute, Bioanalysis and
´
Pharmacology of Bioactive Lipids Laboratory, Chemical and Physico-chemical Analysis of Drugs Unit, UCL-CHAM (7230), Universite catholique de Louvain, Bruxelles,
Belgium, 3 Gladstone Institute of Neurological Disease and Departments of Biochemistry and Biophysics, and Neurology, University of California San Francisco, San
Francisco, California, United States of America, 4 Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of
America
Abstract
Background: Lipids can act as signaling molecules, activating intracellular and membrane-associated receptors to regulate
physiological functions. To understand how a newly discovered signaling lipid functions, it is necessary to identify and
characterize the enzymes involved in their production and inactivation. The signaling lipid N-palmitoylethanolamine (PEA) is
known to activate intracellular and membrane-associated receptors and regulate physiological functions, but little is known
about the enzymes involved in its production and inactivation.
Principal Findings: Here we show that Saccharomyces cerevisiae produce and inactivate PEA, suggesting that genetic
manipulations of this lower
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