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genetic loci involved in antibody response to mycobacterium avium ssp. paratuberculosis in cattle参与鸟结核分枝杆菌抗体反应ssp基因位点。.pdf

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genetic loci involved in antibody response to mycobacterium avium ssp. paratuberculosis in cattle参与鸟结核分枝杆菌抗体反应ssp基因位点。

Genetic Loci Involved in Antibody Response to Mycobacterium avium ssp. paratuberculosis in Cattle 1 . 2.¤ 1,3 1 4 Giulietta Minozzi * , Laura Buggiotti , Alessandra Stella , Francesco Strozzi , Mario Luini , John L. Williams1 1 Parco Tecnologico Padano, Polo Universitario, Lodi, Italy, 2 Istituto Sperimentale Italiano Lazzaro Spallanzani, Lodi, Italy, 3 Istituto di Biologia e Biotecnologia Agraria, Consiglio Nazionale delle Ricerche, Lodi, Italy, 4 Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Lodi, Italy Abstract Background: Mycobacterium avium subsp. paratuberculosis (MAP) causes chronic enteritis in a wide range of animal species. In cattle, MAP causes a chronic disease called Johne’s disease, or paratuberculosis, that is not treatable and the efficacy of vaccine control is controversial. The clinical phase of the disease is characterised by diarrhoea, weight loss, drop in milk production and eventually death. Susceptibility to MAP infection is heritable with heritability estimates ranging from 0.06 to 0.10. There have been several studies over the last few years that have identified genetic loci putatively associated with MAP susceptibility, however, with the availability of genome-wide high density SNP maker panels it is now possible to carry out association studies that have higher precision. Methodology/Principal Findings: The objective of the current study was to localize genes having an impact on Johne’s disease susceptibility using the latest bovine genome information and a high density SNP panel (Illumina BovineSNP50 BeadChip) to perform a case/control, genome-wide association analysis. Samples from MAP case and negative controls were selected fro