galectin-10, a potential biomarker of eosinophilic airway inflammationgalectin-10,嗜酸性气道炎症的潜在生物标志物.pdfVIP
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galectin-10, a potential biomarker of eosinophilic airway inflammationgalectin-10,嗜酸性气道炎症的潜在生物标志物
Galectin-10, a Potential Biomarker of Eosinophilic Airway
Inflammation
1 1 1 1 2
Justin C. Chua , Jo A. Douglass *, Andrew Gillman , Robyn E. O’Hehir , Els N. Meeusen
1 Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital and Monash University, Melbourne, Victoria, Australia, 2 Biotechnology Research
Laboratories, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
Abstract
Measurement of eosinophilic airway inflammation can assist in the diagnosis of allergic asthma and in the management of
exacerbations, however its clinical implementation remains difficult. Galectin-10 has been associated with eosinophilic
inflammation and has the potential to be used as a surrogate biomarker. This study aimed to assess the relationship
between galectin-10 in sputum with sputum eosinophil counts, the current gold standard of eosinophil inflammation in the
lung. Thirty-eight sputum samples were processed for both eosinophil counts by cytospins and semi-quantitative
measurements of galectin-10 by western blots. A strong association was observed between galectin-10 levels in sputum
and sputum eosinophil measurements, and they accurately determined sputum eosinophilia. The results support the
potential for galectin-10 to be used as a surrogate biomarker of eosinophilic airway inflammation.
Citation: Chua JC, Douglass JA, Gillman A, O’Hehir RE, Meeusen EN (2012) Galectin-10, a Potential Biomarker of Eosinophilic Airway Inflammation. PLoS ONE 7(8):
e42549. doi:10.1371/journal.pone.0042549
Editor: Christianne Bandeira de Melo, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil
Received May 31, 2012; Accepted
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