flexibility of a eukaryotic lipidome – insights from yeast lipidomics真核lipidome的灵活性u2014u2014从酵母lipidomics见解.pdfVIP
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flexibility of a eukaryotic lipidome – insights from yeast lipidomics真核lipidome的灵活性u2014u2014从酵母lipidomics见解
Flexibility of a Eukaryotic Lipidome – Insights from Yeast
Lipidomics
. . ¤
Christian Klose , Michal A. Surma , Mathias J. Gerl , Felix Meyenhofer, Andrej Shevchenko, Kai Simons*
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Abstract
Mass spectrometry-based shotgun lipidomics has enabled the quantitative and comprehensive assessment of cellular lipid
compositions. The yeast Saccharomyces cerevisiae has proven to be a particularly valuable experimental system for studying
lipid-related cellular processes. Here, by applying our shotgun lipidomics platform, we investigated the influence of a variety
of commonly used growth conditions on the yeast lipidome, including glycerophospholipids, triglycerides, ergosterol as
well as complex sphingolipids. This extensive dataset allowed for a quantitative description of the intrinsic flexibility of a
eukaryotic lipidome, thereby providing new insights into the adjustments of lipid biosynthetic pathways. In addition, we
established a baseline for future lipidomic experiments in yeast. Finally, flexibility of lipidomic features is proposed as a new
parameter for the description of the physiological state of an organism.
Citation: Klose C, Surma MA, Gerl MJ, Meyenhofer F, Shevchenko A, et al. (2012) Flexibility of a Eukaryotic Lipidome – Insights from Yeast Lipidomics. PLoS
ONE 7(4): e35063. doi:10.1371/journal.pone.0035063
Editor: Michael Polymenis, Texas AM University, United States of America
Received February 3, 2012; Accepted March 12, 2012; Published April 18, 2012
Copyright: 2012 Klose et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the
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