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genomics helps explain why some like it hot基因组学有助于解释为什么热情如火
Open access, freely available online
Synopses of Research Articles
The Ol’ Switcheroo Shows How an RNA Enzyme Splices Itself
DOI: 10.1371/journal.pbio.0030310
Ribonucleic acid (RNA) is a dogma normal enzyme. Then, they replaced the
breaker. The “central dogma” of oxygen in question with a sulfur atom.
cellular biochemistry mandates that The reaction didn’t work as well because,
deoxyribonucleic acid (DNA) stores by the rules of chemistry, sulfur doesn’t
information, and RNA copies this like to bind to magnesium. But sulfur
information and uses it to direct the does like manganese and cadmium
assembly of amino acid building blocks ions. So they replaced the magnesium
into proteins, such as enzymes. Enzymes with one of these other metal ions and
catalyze important chemical reactions measured the reaction. The researchers
in the cell, such as the breakdown of saw that these other metal ions restored
glucose or the synthesis of urea. (or “rescued”) enzymatic activity. In short,
When biochemists discovered catalytic the enzyme needs a bond where the
RNA, they had to ditch the dogma. oxygen and the magnesium are, but the
Because of its structure, it turns out, bond doesn’t have to be between oxygen
RNA can act as an enzyme and catalyze and magnesium. DOI: 10.1371/journal.pbio.0030310.g001
reactions. While two strands of DNA As complicated as that is, plucking
tend to zip up into the famous double out one atom and trading it for another RNA enzymes called ribozymes require
helix, RNA usually goes solo. The single is itself a tricky business. Because most metal atoms
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