genetic evidence supporting the association of protease and protease inhibitor genes with inflammatory bowel disease a systematic review遗传学证据支持协会的蛋白酶和蛋白酶抑制剂基因与炎症性肠病系统回顾.pdfVIP
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genetic evidence supporting the association of protease and protease inhibitor genes with inflammatory bowel disease a systematic review遗传学证据支持协会的蛋白酶和蛋白酶抑制剂基因与炎症性肠病系统回顾
Genetic Evidence Supporting the Association of Protease
and Protease Inhibitor Genes with Inflammatory Bowel
Disease: A Systematic Review
1. ¨ 2,3. 4 ¨ 2,3 5
Isabelle Cleynen , Peter Juni , Geertruida E. Bekkering , Eveline Nuesch , Camila T. Mendes ,
2 5 6 5 1 ´
Stefanie Schmied , Stefan Wyder , Eliane Kellen , Peter M. Villiger , Paul Rutgeerts , Severine
1 5
Vermeire , Daniel Lottaz *
1 Department of Gastroenterology, Catholic University Leuven, Leuven, Belgium, 2 Clinical Trials Unit Bern, Bern University Hospital, Bern, Switzerland, 3 Institute of Social
and Preventive Medicine, University of Bern, Bern, Switzerland, 4 Belgian Centre for Evidence Based Medicine, Katholieke Universiteit Leuven, Leuven, Belgium,
5 Department of Rheumatology, Clinical Immunology and Allergology, University Hospital of Bern, Bern, Switzerland, 6 Leuven Centre for Cancer Prevention, University
Hospital Leuven, Leuven, Belgium
Abstract
As part of the European research consortium IBDase, we addressed the role of proteases and protease inhibitors (P/PIs) in
inflammatory bowel disease (IBD), characterized by chronic mucosal inflammation of the gastrointestinal tract, which affects
2.2 million people in Europe and 1.4 million people in North America. We systematically reviewed all published genetic
studies on populations of European ancestry (67 studies on Crohn’s disease [CD] and 37 studies on ulcerative colitis [UC]) to
identify critical genomic regions associated with IBD. We developed a computer algorithm to map the 807 P/PI genes with
exac
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