healthy lifestyle and leukocyte telomere length in u.s. women美国女性健康的生活方式和白细胞端粒长度.pdfVIP

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healthy lifestyle and leukocyte telomere length in u.s. women美国女性健康的生活方式和白细胞端粒长度.pdf

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healthy lifestyle and leukocyte telomere length in u.s. women美国女性健康的生活方式和白细胞端粒长度

Healthy Lifestyle and Leukocyte Telomere Length in U.S. Women 1,2 3 2,4,5 1,7 1,2,4 Qi Sun *, Ling Shi , Jennifer Prescott , Stephanie E. Chiuve , Frank B. Hu , Immaculata De Vivo2,4,5, Meir J. Stampfer1,2,4, Paul W. Franks1,6, JoAnn E. Manson2,4,7, Kathryn M. Rexrode7 1 Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America, 2 Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, 3 College of Nursing and Health Sciences, University of Massachusetts-Boston, Boston, Massachusetts, United States of America, 4 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, 5 Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, 6 Department of ¨ Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden, 7 Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America Abstract Context: Whether a healthy lifestyle may be associated with longer telomere length is largely unknown. Objectives: To examine healthy lifestyle practices, which are primary prevention measures against major age-related chronic diseases, in relation to leukocyte telomere length. Design and Setting: Cross-sectional analysis in the Nurses’ Health Study (NHS). Participants: The population consisted of 5,862 women who participated in multiple prospective case-contro