sex steroids and bone health status in men男性性类固醇和骨骼健康状况.pdfVIP

Hindawi Publishing Corporation International Journal of Endocrinology Volume 2012, Article ID 208719, 7 pages doi:10.1155/2012/208719 Review Article Sex Steroids and Bone Health Status in Men Kok-Yong Chin and Soelaiman Ima-Nirwana Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia Correspondence should be addressed to Soelaiman Ima-Nirwana, imasoel@medic.ukm.my Received 18 August 2012; Accepted 27 September 2012 Academic Editor: Ling-Qing Yuan Copyright © 2012 K.-Y. Chin and S. Ima-Nirwana. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Male osteoporosis is a health problem which deserves more attention as nearly 30% of osteoporotic fractures happen in men aged 50 years and above. Although men do not experience an accelerated bone loss phase and testosterone deficiency is not a universal characteristic for aged men, osteoporosis due to age-related testosterone deficiency does have a negative impact on bone health status of men. Observations from epidemiological studies indicate that elderly men with higher testosterone can preserve their BMD better and thus are less prone to fracture. Observations on men with estrogen resistance or aromatase deficiency indicate that estrogen is equally important in the maintenance of bone health status. This had been validated in several epidemiological studies which found that the relationships between estrogen and bone health indices are significant and sometimes stronger than testosterone. Studies on the relationship between quantitative ultrasound and bone r