sirna efficiency structure or sequence—that is the question核效率结构或序列,是个问题.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2006, Article ID 83757, Pages 1–7 DOI 10.1155/JBB/2006/83757 Review Article siRNA Efficiency: Structure or Sequence—That Is the Question Jens Kurreck Institute for Chemistry and Biochemistry, Free University Berlin, Thielallee 63, 14195 Berlin, Germany Received 26 January 2006; Accepted 3 April 2006 The triumphant success of RNA interference (RNAi) in life sciences is based on its high potency to silence genes in a sequence- specific manner. Nevertheless