the observation of humoral responses after influenza vaccination in patients with rheumatoid arthritis treated with japanese oriental (kampo) medicine an observational study体液反应的观察在治疗类风湿性关节炎患者接种流感疫苗后与日本东方(邮政寿险局)药一项观察性研究.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 320542, 6 pages doi:10.1155/2012/320542 Research Article The Observation of Humoral Responses after Influenza Vaccination in Patients with Rheumatoid Arthritis Treated with Japanese Oriental (Kampo) Medicine: An Observational Study Toshiaki Kogure,1 Naoyuki Harada,1 Yuko Oku,2 Takeshi Tatsumi,1 and Atsushi Niizawa3 1 Department of Japanese Oriental Medicine, Gunma Central and General Hospital, Maebashi Gunma 371-0025, Japan 2 Department of Internal Medicine, Gunma Central and General Hospital, Maebashi Gunma 371-0025, Japan 3 Department of Japanese Oriental Medicine, Kobe Century Memorial Hospital, Japan Correspondence should be addressed to Toshiaki Kogure, gch-kogure@kl.wind.ne.jp Received 2 December 2011; Accepted 1 February 2012 Academic Editor: Vincenzo De Feo Copyright © 2012 Toshiaki Kogure et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. The efficacy of influenza vaccination in patients treated with Japanese Oriental (Kampo) Medicine is unknown. The objectives of this study were to observe the efficacy of influenza vaccination in RA patients treated with Kampo. Methods. Trivalent influenza subunit vaccine was administered to 45 RA patients who had received Kampo. They were divided into 2 groups: RA patients treated without MTX (“without MTX group”) and treated with MTX (“with MTX group”). Antibody titers were measured before and 4 weeks after vaccination using hemagglutination inhibition assay. Results. Geometric mean titers (GMTs) of anti- influenza antibodies significant