the role of salt in the pathogenesis of fructose-induced hypertension盐的作用fructose-induced高血压的发病机理.pdfVIP

SAGE-Hindawi Access to Research International Journal of Nephrology Volume 2011, Article ID 392708, 8 pages doi:10.4061/2011/392708 Review Article The Role of Salt in the Pathogenesis of Fructose-Induced Hypertension Manoocher Soleimani1, 2, 3 and Pooneh Alborzi4 1 The Center on Genetics of Transport and Epithelial Biology, University of Cincinnati, 231 Albert Sabin Way, MSB 6312, Cincinnati, OH 45267-0585, USA 2 Research Services, Veterans Aff airs Medical Center, Cincinnati, OH 45220, USA 3 Department of Internal Medicine, University of Cincinnati, 231 Albert Sabin Way, MSB 6312, Cincinnati, OH 45267-0585, USA 4 Pennsylvania Hospital, University of Pennsylvania Health System, Philadelphia, PA 19107, USA Correspondence should be addressed to Manoocher Soleimani, soleimm@ Received 19 January 2011; Revised 14 April 2011; Accepted 30 April 2011 Academic Editor: Anil K. Agarwal Copyright © 2011 M. Soleimani and P. Alborzi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Metabolic syndrome, as manifested by visceral obesity, hypertension, insulin resistance, and dyslipidemia, is reaching epidemic proportions in the Western World, specifically the United States. Epidemiologic studies suggest that the increased prevalence of metabolic syndrome directly correlates with an increase in the consumption of fructose, mainly in the form of high-fructose corn syrup. This inexpensive alternative to traditional sugar has been increasingly utilized by the food industry as a sweetener since the 1960s. While augmented caloric intake and sedentary lifestyles play important roles in the increasing prevalence of obesit