A DiscreteParticle Model of Blood Dynamics in （一个DiscreteParticle血液动力学的模型）.pdfVIP

A Discrete-Particle Model of Blood Dynamics in Capillary Vessels 1,2 2 Witold Dzwinel , Krzysztof Boryczko and David A.Yuen 1 AGH Institute of Computer Science, A l.Mickiewicza 30, 30 -059, Kraków, Poland 2 Minnesota Supercomputer Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA Abstract We investigate the physical mechanism of aggregation of red blood cells (RBC) in capillary vessels, using a discrete particle model. This model can accurately capture the scales from 0.001m to 100m, far below the scales, which can be modeled numerically with classical computational fluid dynamics. We use a discrete-particle model in 3D for modeling the flow of plasma and RBCs in a capillary tube. The two situations involving necking and no necking have been considered. The flexible viscoelastic red blood cells and the walls of the elastic vessel are made up of solid particles held together by elastic harmonic forces. The blood plasma is represented by a system of dissipative fluid particles. We have simulated the flow of cells of different shapes, such as normal and “sickle” cells. The cells coagulate in spite of the absence of adhesive forces in the model. The total number of fluid and solid particles used ranges from 1 to 3 million. We conclude that aggregation of red blood cells in capillary vessels is stimulated by depletion forces and hydrodynamic interactions. The cluster of “sickle” cells formed in the necking of the con