Digital Signal Processing Using MATLAB174;V（数字信号处理使用MATLAB174;V）.pdf

计算生物学 Computational Biology Chaochun Wei ( 韦朝春) ccwei@ /~ccwei Fall 2013 1 Contents Background Course information Goal Contents Organization Grading Some examples about Computational Biology 2 A Big Picture of Biology “Biology is an information science” -- Leroy Hood /biofuels/ 3 Bioinformatics/ Computational Biology / Systems Biology 4 Bioinformatics The science of collecting and analyzing complex biological data such as genetic codes. -- Oxford Dictionary Major research areas  Sequence analysis  Genome annotation  Computational evolutionary biology  Analysis of gene expression, regulation  Comparative genomics  Literature analysis  Biological systems modeling  Structural Biology 5 Milestone of modern biology： the human genome project Feb. 15, 2001 Nature Feb. 16, 2001 Science 6 Human Genome Project 3 billion dollars，3 billion residues “This is ...  a WASTE of tax payers’ money…. We can do a lot more George Church Professor of Genetics Harvard Medical School 7 Automated high throughput sequencing AGAACGACCATCAACTAAATCAAAATGCCTTTCAAACCAGCA GACAACCCAAAATGCCCAAAATGCGGCAAATCCGTATACGCC GCNGAAGA