肠促胰素的共识——dpp-4部分解读（Consensus on incretin a partial interpretation of DPP-4）.docVIP

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肠促胰素的共识——dpp-4部分解读（Consensus on incretin a partial interpretation of DPP-4）.doc

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肠促胰素的共识——dpp-4部分解读（Consensus on incretin a partial interpretation of DPP-4）

肠促胰素的共识——dpp-4部分解读（Consensus on incretin a partial interpretation of DPP-4） Consensus on incretin: a partial interpretation of DPP-4 In November 22nd, Chinese Diabetes Society in the Seventeenth National Academic Conference (CDS2013), the Chinese Diabetes Society chairman, honorary vice chairman of the Asian Diabetes Association, endocrine metabolic disease center director of China-Japan Friendship Hospital professor Yang Wenying shared the incretin consensus - two dipeptidyl peptidase 4 (DPP-4). The. The reason why DPP-4 inhibitors, which are produced by the incretin mechanism, is now popular, and the important reason is that the mechanisms of these drugs are completely different from those of other antidiabetic drugs currently on the market. Its mechanism of action in humans is as follows: in the islet, it can also stimulate the secretion of the beta cell insulin secretion and inhibit glucagon, and this mechanism is dependent on the concentration of glucose, which can prevent the occurrence of hypoglycemia; in addition, it can also inhibit appetite, can not increase the weight in good glycaemic control. Mechanism of action of DPP-4 inhibitors By inhibiting the activity of DPP-4, the inactivation of GLP-1 was effectively reduced, and the level of active GLP-1 was increased in physiological range. The known GLP-1 can stimulate insulin and glucagon inhibition, inhibition of gastric emptying and islet cell rebirth to reduce blood glucose, glucose is mainly in a concentration dependent manner to promote the release of insulin and reduce the level of glucagon, play the decrease of HbA1c, blood glucose and postprandial blood glucose after the fasting, so Yang Wenying said it was a hypoglycemic intelligent method. DPP-4 inhibitors inactivate DPP-4 and do not decompose GLP-1. Overall efficacy of DPP-4 inhibitors At present, the DPP-4 inhibitors have been listed in China include Sig Leo Dean, Shah Glenn Dean, Vee Glenn Dean, glibenclamide, A Glenn Dean and so on. According