胰腺癌分子靶向治疗（Molecular targeted therapy for pancreatic cancer）.doc

胰腺癌分子靶向治疗（Molecular targeted therapy for pancreatic cancer） Molecular targeted therapy for pancreatic cancer Molecular targeted therapy According to tumor molecular events, that is, a tumor cell has a gene or its gene expression products (such as proteins, etc.) as the treatment Target reverses the malignant biological behavior of tumor from molecular level (such as proliferation, differentiation, recurrence, metastasis, chemotherapy, drug resistance, radiation resistance, and fine Apoptosis, neovascularization and so on, so as to achieve the purpose of prevention and treatment of tumors. In general, molecular targeting therapy targets the difference between tumor cells and normal cells, attacking only tumor cells and normal cells It sounded very small. Pancreatic cancer, molecular targeted therapy, drug classification EGFR monoclonal antibody targeting drug [tyrosine kinase inhibitors (EGFR-TKI)] Anti vascular endothelial growth factor (VEGF) targeting drugs Matrix metalloproteinase inhibitors (MMPIs) The farnesyl transferase inhibitor (FTIs) ? other molecular targeted therapies and immunotherapy drugs EGFR is a transmembrane receptor of tyrosine kinase, and plays a key role in cell growth, repair and functional differentiation. EGFR monoclonal antibody, It can competitively bind to the extracellular portion of EGFR, reduce phosphorylation by receptor ligand binding, and interfere with EGFR mediated signal transduction Pathway, thereby promoting apoptosis and inhibiting tumor growth and metastasis. At the same time, it can inhibit the blood indirectly by lowering VEGF and other related factors Guan Shengcheng and tumor metastasis. Study of EGFR monoclonal antibody targeting drug: Cetuximab (Cetuximab) combined with GEM: The initial dose of Cetuximab was 400mg/m2, first weeks, followed by 250mg/m2 per week for 7 consecutive weeks; GEM, 1000, mg/m2, and even Take 7 weeks for 1 weeks, and then GEM takes 3 weeks every 4 weeks, while Cetuximab is given 1 times a week Re