解热镇痛药（Antipyretic analgesics）.docVIP

解热镇痛药（Antipyretic analgesics） * grasp the combined action and action mechanism of antipyretic and analgesic drugs * grasp the pharmacological effects, clinical applications, in vivo processes and adverse reactions of aspirin * familiarity with the role, application, and adverse effects of acetaminophen, indomethacin and Bloven * understanding the characteristics of selective COX-2 inhibitors Overview of antipyretic, analgesic and anti-inflammatory drugs Nonsteroidal anti-inflammatory drugs, prostaglandin inhibitors, aspirin drugs Antipyretic analgesics and anti-inflammatory drugs have a common pharmacological effect 1. antipyretic action (Antipyretic, Effect) Features: lower the body temperature of the fever and have no effect on the body temperature of normal subjects: inhibition of PGs synthesis (PGs is a heat generating substance) Comparison of the effects of antipyretic, analgesic and antiinflammatory drugs and chlorpromazine on body temperature medicine Antipyretic Normal body temperature Dissipate heat Heat production Mechanism of action NSAIDs + - Arrows - The decrease in PGs synthesis chlorpromazine + Here (physical cooling) Arrows Here The lower body temperature regulating center 2. analgesic effect (Analgesic, Effect) It has a moderate analgesic effect and is ineffective for severe traumatic pain and visceral smooth muscle colic; Clinical application: for chronic blunt pain, such as headache, toothache, neuralgia, muscle or joint pain, dysmenorrhea and so on, it has a good analgesic effect; Not producing euphoria and addiction, and is widely used in clinic. Comparison of analgesic effects between NSAIDs and opioid analgesics medicine Action site Mechanism of action Action property Addictive NSAIDs Peripheral Inhibition PGs synthesis Chronic blunt pain No addiction Analgesic The central administration Opioid receptor All kinds of pain Addictive 3., anti-inflammatory effect (Anti-inflammatory, Effect) * PGs is both a pain inducing substance and a proinflamma