贲门失弛症治疗方法的评价（Evaluation of the treatment of achalasia）.docVIP

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贲门失弛症治疗方法的评价（Evaluation of the treatment of achalasia）.doc

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贲门失弛症治疗方法的评价（Evaluation of the treatment of achalasia）

贲门失弛症治疗方法的评价（Evaluation of the treatment of achalasia） Overview Evaluation of the treatment of achalasia Chinese Academy of Medical Sciences Peking Union Medical College Hospital Department of thoracic surgery Ge Feng Li Zejian Ke Meiyun Achalasia is the clinical manifestation of the lower resting pressure of the lower esophageal sphincter, the lack of relaxation during swallowing, and the lack of dynamic peristalsis in the esophagus. In 1989, Wongs immunological studies showed that achalasia was associated with an abnormal immune system, [1]. At present, there is no way to make esophageal peristalsis and lower esophageal sphincter function return to normal, the purpose of treatment is limited to the relief of functional obstruction. Based on this, there are 4 widely used treatment methods. General treatment involves psychotherapy and dietary regulation. Early church patients adjust themselves to relieve symptoms. Two 、 drug treatment commonly used anticholinergic drugs, alpha adrenergic receptor blockers, calcium antagonists and three nitroglycerin and other four kinds of drugs. Currently, calcium antagonists, commonly known as calcium antagonists, are considered different from other antispasmodic drugs, and they do not reduce the resting pressure of the lower esophageal sphincter (LESP). After taking 20mg 26 minutes (normal 19.5 minutes), the blood drug concentration reached the most effective peak, can reduce LESP32.2 + 3.55mmHg (normal people decreased by 18.4 + 2.04mmHg) [2]. Ke Meiyun reported the treatment of achalasia with achalasia, and its curative effect is obviously superior to that of heartburn [3]. Three, cardiac dilatation of Thomas Willis for the first time in 1672 by whale shall be made to a female bougie, patients with esophageal dilatation, maintain their lives more than 15 years. Since 1898, Schroilerg used balloon borne balloon dilatation of the cardia as the precursor of balloon dilatation. The principle of dilatation of the cardia in the esoph