THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. …(《生物化学》杂志上。卷u2026).pdf

THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. …(《生物化学》杂志上。卷u2026).pdf

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THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. …(《生物化学》杂志上。卷u2026)

THEJOURNALOF BIOLOGICAL CHEMISTRY Vol. 257, No. 11. Issue of June 10, pp. 6016-6022, 1982 PrinIed in U.S.A. The Structure of Melittin 11.INTERPRETATION OF THE STRUCTURE* (Received for publication, July 13, 1981) Thomas C. Terwilligert and David Eisenbergg The MolecularBiology Institute andDepartment of Chemist?, University of California, Los Angeles, Californ.ia 90024 Melittin, a small protein containing 26 amino acid Reflecting these properties, the primary structure of melittin residues, isthe principal toxic componentof bee venom. is amphiphilic. Thirteen of the first 20 residues are hydropho- It is water-soluble as a tetramer, but it spontaneously bic and only two are charged, while four of the last six are integrates intolipid bilayers and is thought to act as a charged andthe remaining two are polar. The complete lytic agent. We describe here the three-dimensional sequence of melittin is as follows (26). structure of tetrameric melittin as determined by x-ray crystallographic analysis at 2-A resolution. The struc- NH2-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Th-Gly-Leu-Pro- ture is discussed in terms of the interactionsbetween 1 7 14 the fourpolypeptide chains and is related to NMR and Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-GIn-Gln-CONH~ 15 21 26 CD experiments of others.

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