外照射配合-%27252-锎中子射线腔内照射治疗食管癌临床随机的研究.pdfVIP

中文 摘 妥 亡，因此该例患者食管晚期反应被评定为V级 (3.6%)，两组 中均未观察到W级食管晚期反应的出现。截止到随访日，两 组各有3例患者发现远处转移，转移部位分别为肺、锁上淋 巴结和骨，转移率分别为 13.6%和 10.7 ，两组间无显著性 差异 (P0.05). 结论:加速器外照射配合252钢中子射线腔内照射治疗食 管癌，两组近期疗效、1年局控率和生存率均较高，但统计学 均无显著性差异。食管急性反应发生率较高，但患者能耐受， 可以完成放射治疗，252钢中子射线腔内照射配合加速器外照 射治疗食管癌临床具有一定的可行性。但晚期反应及远期疗 效尚有待进一步随访观察。 关健词:食管癌;放射治疗:内照射/后装治疗 252钢;毒性反应 英 文 摘 要 AclinicalrandomizedstudyofCf-252intracavitary radiationcombinedwithexternal-beam irradiationin thetreatmentofesophagealcarcinoma. ABSTRACT Objective:Toevaluatethetoxicityandtherapeuticefficacy external-beamirradiationcombinedwithCf-252intracavitary radiationinthetreatmentofesophagealcarcinomainaclinical randomizedtrial. Methods:FromJanuarytoDecember,2004,fiftypatients whowereeligibleforthefollowingselectioncriterawere randomizedintotwogroups:externalbeam combinedwith Cf-252intracavitarytwicegroup(EBIR-2)andexternalbeam combinedwithCf-252intracavitarythreetimesgroup(EBIR-3). InEBIR-2group,22patientswerefirsttreatedwithconventional fractionatedradiationtoadoseof40Gyover4weeks,thenwith externalandintracavitaryradiationconcomitantly(5.OGyper fraction,onceaweekto10Gyin2fractions),withexternal irradiationskippedonthedayofintracavitaryradiation.Thetotal doseofexternalirradiationwas50Gy.InEBIR-3group,28 patientswere firsttreated with conventionalfractionated radiationtoadoseof30Gyover3weeks,thenwithexternaland intracavitaryradiationconcomitantly(3.5Gyperfraction,oncea weekto10.5Gyin3fractions),withexternalirradiationskipped onthedayofintracavitaryradiation,andthetotaldoseof externalirradiationalsowas50Gy， 5 — 一— --一一 英 文 摘 要 The selection critera includedhistologically proven squamouscellcarcinoma,tumor10cm inlengthonbarium swallow;KPS}70,age18-70years,primarydiseaseinthe esophagus，nopriormaling