男性及女性乳腺癌患者临床病理对照分析.pdfVIP

摘 要 男性与女性乳腺癌患者临床病理对照分析 研究生：王 平 导师：吐鲁鸿 副教授 摘 要 目的：比较男性和女性乳腺癌患者的临床、病理、分子生物学特点，为优化男 性乳腺癌患者的综合治疗提供参考。方法：收集新疆医科大学附属肿瘤医院2002年1 月～2009年6月行手术治疗的Ⅰ～Ⅲ期乳腺癌患者资料，其中男性39例，女性156例， 按患者就诊时年龄、出现症状或体征到就诊的间隔时间、病理类型、肿瘤大小、腋 窝淋巴结转移状况、TNM分期、ER 、PR 、C-erbB-2的表达状况等资料进行比较分析。 结果：与女性乳腺癌患者相比，男性乳腺癌患者发病年龄偏大，大于50岁者多见（P ＜0.001 ）；从出现症状或体征到就诊时间比女性患者要晚（P=0.031 ）；腋窝淋巴结转 移者多（P=0.036 ）；肿瘤TNM分期以Ⅱ、Ⅲ期为主（P=0.042 ）；ER 、PR 阳性表达者 较多（P=0.008,P=0.001) ；ER(+)和/或PR(+),C-erbB-2(-)者所占的比例较大,而ER(-)和 PR(-),C-erbB-2(+)者所占的比例较小（P=0.038 ）；肿瘤大小、病理类型及C-erbB-2表 达无明显差异，无统计学意义，P ＞0.05 。结论：男性乳腺癌患者的预后指标可能较 女性差。提示早发现、早诊断以及个体化综合治疗是关键。 关键词: 男性乳腺癌；临床与病理学特征；分子生物学 —1— 新疆医科大学医学硕士学位论文 Analysis of clinical and pathological characteristics between male and female patients with breast cancer Postgraduate: Wang Ping Supervisor: associate Professor Tu Lu hong Abstract Objective：A single institute review of the clinical presentation, pathological and molecular biological characteristics between male breast cancer patients and female breast cancer patients, collection comprehensive data on clinicalpathological presentation and management of male breast cancer may help to optimize the Clinical care. Methods ： Male and female breast cancer patients in Stage Ⅰ～Ⅲ were enrolled from January 2002 to June 2009 in Affiliated cancer Hospital of Xin jiang Medical University, Including 39 male patients and 156 female patients, clinical and pathological feature were analyzed in two groups, including age at first diagnosis, the interval between initial symptom and first diagnosis, histologic type, tumor size, axillary lymph node status, cTNM stage, estrogen receptor (ER) status, progesterone rece