a genome-wide genetic signature of jewish ancestry perfectly separates individuals with and without full jewish ancestry in a large random sample of european americans全基因组基因签名的犹太血统完全分离的个人使用和不完整的犹太祖先在一个大型欧洲美国人的随机样本.pdfVIP

Volume 10, Issue 1, Article R7Needet al.2009 Open Access Research A genome-wide genetic signature of Jewish ancestry perfectly separates individuals with and without full Jewish ancestry in a large random sample of European Americans Anna C Need, Dalia Kasperavičiūtė, Elizabeth T Cirulli and David B Goldstein Address: Center for Human Genome Variation, Institute for Genome Sciences and Policy, Research Drive, Duke University, Durham, NC 27708, USA. Correspondence: David B Goldstein. Email: d.goldstein@ Published: 22 January 2009 Received: 19 September 2008 Revised: 16 December 2008 Genome Biology 2009, 10:R7 (doi:10.1186/gb-2009-10-1-r7) Accepted: 22 January 2009 The electronic version of this article is the complete one and can be found online at /2009/10/1/R7 © 2009 Need et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. cluster from those individuals with no Jewish ancestry./pGenomes and Jewish ancestrypA principal components analysis of genomic information showed that individuals with full Jewish ancestry formed a clearly distinct Abstract Background: It was recently shown that the genetic distinction between self-identified Ashkenazi Jewish and non-Jewish individuals is a prominent component of genome-wide patterns of genetic variation in European Americans. No study however has yet assessed how accurately self-identified (Ashkenazi) J