a new, effective and high-yield approach for identifying liver tumor suppressors一个新的、有效和高收益的方法识别肝肿瘤的抑制.pdfVIP

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a new, effective and high-yield approach for identifying liver tumor suppressors一个新的、有效和高收益的方法识别肝肿瘤的抑制.pdf

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a new, effective and high-yield approach for identifying liver tumor suppressors一个新的、有效和高收益的方法识别肝肿瘤的抑制

Minireview AA nneeww,, eeffffeeccttiivvee aanndd hhiigghh--yyiieelldd aapppprrooaacchh ffoorr iiddeennttiiffyyiinngg lliivveerr ttuummoorr ssuupppprreessssoorrss Esra Olgun* and Lewis R Roberts† Addresses: *Department of Internal Medicine, McLaren Regional Medical Center, 401 S Ballenger Highway, Flint, Michigan 48532, USA. †Miles and Shirley Fiterman Center for Digestive Diseases, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA. Correspondence: Lewis R Roberts. Email: roberts.lewis@ Published: 26 February 2009 Genome Medicine 2009, 11::26 (doi:10.1186/gm26) The electronic version of this article is the complete one and can be found online at /content/1/2/26 © 2009 BioMed Central Ltd AAbbssttrraacctt Despite recent advances in research in hepatocarcinogenesis, we still lack a comprehensive view of the major pathways involved in liver carcinogenesis. Current concepts suggest that a limited number of molecular alterations involving oncogene activation and tumor suppressor inhibition are responsible for initiation of cancer. A recent publication by Zender et al. utilizes a combi- nation of high-resolution comparative genomic hybridization, short hairpin RNA inhibition of target genes at the locations of focal genomic deletions, and a primed cell mosaic mouse model to identify novel tumor suppressors in hepatocellular carcinoma. This exciting new model promises to provide additional insights into the mechanisms of carcinogenesis. IInnttrroodduuccttiioonn the inherent ability to activate tumor suppressor genes or Hepatocellular carcinoma (HCC) is the fifth most common pathways through oncogene-induced apop