acquisition of rifabutin resistance by a rifampicin resistant mutant of mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency收购利福抗利福平耐药突变的结核分枝杆菌是一个不同寻常的突变谱和高频率.pdfVIP

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acquisition of rifabutin resistance by a rifampicin resistant mutant of mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency收购利福抗利福平耐药突变的结核分枝杆菌是一个不同寻常的突变谱和高频率.pdf

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acquisition of rifabutin resistance by a rifampicin resistant mutant of mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency收购利福抗利福平耐药突变的结核分枝杆菌是一个不同寻常的突变谱和高频率

Annals of Clinical Microbiology and Antimicrobials BioMed Central Research Open Access Acquisition of rifabutin resistance by a rifampicin resistant mutant of Mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency 1 1 1 2 Richard M Anthony* , Anja RJ Schuitema , Indra L Bergval , Tim J Brown , 1 1 Linda Oskam and Paul R Klatser Address: 1KIT (Royal Tropical Institute) Biomedical Research, Meibergdreef 39, 1 105 AZ Amsterdam, The Netherlands and 2Health Protection Agency, Mycobacterium Reference Unit, Kings College Hospital (Dulwich), London, UK Email: Richard M Anthony* - r.anthony@kit.nl; Anja RJ Schuitema - a.schuitema@kit.nl; Indra L Bergval - i.bergval@kit.nl; Tim J Brown - Tim.Brown@kingsch.nhs.uk; Linda Oskam - l.oskam@kit.nl; Paul R Klatser - p.klatser@kit.nl * Corresponding author Published: 15 June 2005 Received: 14 April 2005 Accepted: 15 June 2005 Annals of Clinical Microbiology and Antimicrobials 2005, 4:9 doi:10.1186/1476- 0711-4-9 This article is available from: /content/4/1/9 © 2005 Anthony et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Mutations in a small region of the