asthma eosinophil disease, mast cell disease, or both嗜酸性粒细胞哮喘疾病,肥大细胞疾病,或两者兼而有之.pdfVIP

ORIGINAL ARTICLE Asthma: Eosinophil Disease, Mast Cell Disease, or Both? Peter Bradding, DM, FRCP Although there is much circumstantial evidence implicating eosinophils as major orchestrators in the pathophysiology of asthma, recent studies have cast doubt on their importance. Not only does anti-interleukin-5 treatment not alter the course of the disease, but some patients with asthma do not have eosinophils in their airways, whereas patients with eosinophilic bronchitis exhibit a florid tissue eosinophilia but do not hav