cgal computing genome assembly likelihoodscgal计算基因组组装可能.pdfVIP

Rahman and Pachter Genome Biology 2013, 14:R8 /2013/14/1/R8 METHOD Open Access CGAL: computing genome assembly likelihoods Atif Rahman1 and Lior Pachter1,2* Abstract Assembly algorithms have been extensively benchmarked using simulated data so that results can be compared to ground truth. However, in de novo assembly, only crude metrics such as contig number and size are typically used to evaluate assembly quality. We present CGAL, a novel likelihood-based approach