威豪泌尿研究.docxVIP

Science Heads科学带头人Key Message关键信息WALTHAM has contributed to the understanding of urinary tract health in dogs by:通过以下方式，威豪?成功地促进了对猫尿道健康领域的理解：Developing novel methodologies for urine collection and analysis.Discovering that the increased risk of urolithiasis in smaller breeds is in part because they pass more concentrated urine with a higher pH less often than larger breed dogs.Demonstrating the benefits of urinary dilution through dietary moisture (small dogs) and dietary sodium (all dogs), and generating insights around the benefits of wet foods for urinary tract health in small dogs.Establishing that dietary calcium is relatively more important than dietary oxalate in influencing the risk of calcium oxalate formation in small breed dogs.Demonstrating that a diet with controlled levels of dietary calcium and oxalate reduces the risk of calcium oxalate urolith recurrence in dog.开发出小便收集与分析的新方法；发现较小体型的犬种发生尿石症的风险有所增加的部分原因是，这些犬种尿液更加浓缩、pH值较高以及次数较少；证明通过饮食中的水分含量（小型犬）与钠（所有犬种）的控制进行尿液稀释是有益的解决方案，并形成关于湿性食物对小型犬的尿道健康的作用方面的见解；确立在影响小型犬草酸钙形成风险方面，饲粮中的钙含量比其中的草酸盐相对更加重要的论断；证明钙与草酸含量受限的饮食有助于降低狗的草酸钙尿石复发风险。Background背景Urolithiasis can be defined as the formation of sediment anywhere within the urinary tract, consisting of one or more poorly soluble crystalloids of urine. The condition starts with the formation of urinary crystals that may in the right conditions, progress to form uroliths (stones) within the urinary tract. In dogs, uroliths are most commonly found in the bladder; kidney uroliths have also been diagnosed, but to a far lesser extent. Uroliths form when urine becomes supersaturated with respect to the ionic components of a specific stone type, leading to crystal precipitation, coagulate and growth.尿结石是指在尿道中某处形成的由一种或多种难溶性尿液晶体所组成的沉淀物。该疾病的症状从尿结晶形成开始，尿结晶在一定的条件下可以在尿道中发展成为尿石（结石）。对于狗而言，膀胱是最常生长尿石的器官；此外，肾尿石也有发生，但几率要远远低于膀胱尿石。在某种结石离子成分过度饱和的状态下，尿液中就会形成这种结石的晶体，然后不断凝结和增大，最后就会形成尿石。?Factors influencing the risk of urolithiasis in dogs include the concentration of the solutes involved, urine p