CRFR1受体拮抗剂对幼年大鼠快眼动睡眠的影响.PDFVIP

86 Chin J Appl Physiol 2010;26( 1) CRF R1 * 1 1 1 1 2 1, 3! 刘学东, 樊红琨 , 张桂红, 王书春, 张 朝, 冯平福 ( 1. , , 450001; 2. , 210046; 3. Case Western Reserve , , 44106) : 观察腹腔注射CRF R1 受体拮抗剂NBI27914 对幼年大鼠 眠/ 觉醒周期的影响: 生后 13 d 的大鼠行电极安装术, 术后12 h 开始多导 眠描记, 描记的第6 h 分别给予腹腔注射不同剂量的NBI27914阿托品 和等量生理盐水: 与基础水平相比, 腹腔注射任何剂量NBI27914 使 幼年大鼠快眼动( REM) 眠均显著减 少, 同时伴随着非快眼动( NREM) 眠的增加, 而生理盐水组无显著变化; 阿托品组的大鼠REM 眠也显著减少, 伴随的是觉醒的增加: 阻断CRF R1受体可以剥夺幼鼠的REM 眠 幼年大鼠; NBI27914; CRF; REM 眠 R338. 63 A 2010) 0108604 Effects of crf receptor antagonist on rem sleep in neonatal rat 1 1 1 1 2 3 LIU Xuedong , FAN Hongkun , ZHANG Guihong , WANG Shuchun , ZHANG Zhao , FENG Pingfu ( 1. Department of Physiology , Medical School in Zhengzhou University, Zhengzhou 450052, China; 2. Institute of Molecular and Cellular Biology, College of Life science in Nanjing Normal University, Nanjing 210097, China; 3. Division of Pulmonary, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106) ABSTRACT Objective: To observe the role of NBI27914, a CRF R1 receptor antagonist, in the regulation of neonatal sleep/ wake cycle. Methods: Rat pups were surgically implantedwith electrodes at postnatal day(PN) 13. At PN 14, 6 hours polysomnographic recording data were continuously collected before and after administration of various doses of NBI 27914, atropine and the same amount of saline. Results: Compared with baseline, rapid eye movement( REM) sleep was significantly reduced andwas replaced primarily by nonREM( NREM) sleep in all grou