computational optical biopsy计算光学切片.pdfVIP

BioMedical Engineering OnLine BioMed Central Research Open Access Computational optical biopsy 1 2 1,2 Yi Li* , Ming Jiang and Ge Wang Address: 1Department of Mathematics, University of Iowa, Iowa City, IA 52242, USA and 2Bioluminescence Tomography Laboratory, Departments of Radiology and Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA Email: Yi Li* - yi-li@; Ming Jiang - ming-jiang@; Ge Wang - ge-wang@ * Corresponding author Published: 14 June 2005 Received: 01 April 2005 Accepted: 14 June 2005 BioMedical Engineering OnLine 2005, 4:36 doi:10.1186/1475-925X-4-36 This article is available from: /content/4/1/36 © 2005 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Molecular imagingoptical imagingfluorescent imagingbioluminescent imaginginverse problemdiffusion approximation Abstract Optical molecular imaging is based on fluorescence or bioluminescence, and hindered by photon scattering in the tissue, especially in patient studies. Here we propose a computational optical biopsy (COB) approach to localize and quantify a light source deep inside a subject. In contrast to existing optical biopsy techniques, our scheme is to collect optical signals directly from a region of interest a