a great barrier reef sinularia sp. yields two new cytotoxic diterpenes大堡礁sinularia sp。收益率两个新的细胞毒性二萜.pdfVIP

Mar. Drugs 2012, 10, 1619-1630; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article A Great Barrier Reef Sinularia sp. Yields Two New Cytotoxic Diterpenes Anthony D. Wright †, Jonathan L. Nielson ‡, Dianne M. Tapiolas, Catherine H. Liptrot § and Cherie A. Motti * Australian Institute of Marine Science, PMB no. 3, Townsville MC, Townsville, QLD 4810, Australia; E-Mails: adwright@ (A.D.W.); jonathon.nielson@ (J.L.N.); d.tapiolas@.au (D.M.T.); catherine.liptrot@.au (C.H.L.) † Present address: College of Pharmacy, University of Hawaii, 34 Rainbow Drive, Hilo, HI 96720, USA. ‡ Present address: ACD Labs UK, Building A, Trinity Court, Wokingham Road, Bracknell, Berkshire RG42 1PL, UK. § Present address: Advanced Analytical Centre, James Cook University, Townsville, QLD 4811, Australia. * Author to whom correspondence should be addressed; E-Mail: c.motti@.au; Tel.: +61-7 Fax: +61-7 Received: 4 June 2012; in revised form: 25 June 2012 / Accepted: 23 July 2012 / Published: 31 July 2012 Abstract: The methanol extract of a Sinularia sp., collected from Bowden Reef, Queensland, Australia, yielded ten natural products. These included the new nitrogenous diterpene (4R*,5R*,9S*,10R*,11Z)-4-methoxy-9-((dimethylamino)-methyl)-12,15-epoxy-11 (13)-en-decahydronaphthalen-16-ol (1), and the new lobane, (1R*,2R*,4S*,15E)-loba-8,10, 13(14),15(16)-tetraen-17,18-diol-17-acetate (2). Also isolated were two known cembranes, sarcophytol-B and (1E,3E,7E)-11,12-epoxycembratrien-15-ol, and