a graphical user interface for a method to infer kinetics and network architecture (mikana)图形用户界面的方法来推断动力学和网络体系结构(mikana).pdfVIP

A Graphical User Interface for a Method to Infer Kinetics and Network Architecture (MIKANA) ´ ˜ 1 2 3,4 5,6 Marcio A. Mourao , Jeyaraman Srividhya , Patrick E. McSharry , Edmund J. Crampin , Santiago Schnell1,7,8* 1 Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, 2 The Biocomplexity Institute, Department of Physics, Indiana University, Bloomington, Indiana, United States of America, 3 Smith School of Enterprise and the Environment, University of Oxford, Oxford, United Kingdom, 4 Mathematical Institute, University of Oxford, Oxford, United Kingdom, 5 Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand, 6 Department of Engineering Science, University of Auckland, Auckland, New Zealand, 7 Center for Computational Medicine Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, 8 Brehm Center for Diabetes Research, University of Michigan Medical School, Ann Arbor, Michigan, United States of America Abstract One of the main challenges in the biomedical sciences is the determination of reaction mechanisms that constitute a biochemical pathway. During the last decades, advances have been made in building complex diagrams showing the static interactions of proteins. The challenge for systems biologists is to build realistic models of the dynamical behavior of reactants, intermediates and products. For this purpose, several methods have been recently proposed to deduce the reaction mechanisms or to estimate the kinetic parameters of the elementary reactions that constitute the pathway. One such meth