a new cytotoxic sesquiterpene quinone produced by penicillium sp. f00120 isolated from a deep sea sediment sample青霉菌产生的一种新的细胞毒性倍半萜烯醌sp。f00120孤立从深海沉积物样品.pdfVIP

Mar. Drugs 2012, 10, 106-115; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp. F00120 Isolated from a Deep Sea Sediment Sample 1 1 1 2 1 1 Xiuping Lin , Xuefeng Zhou , Fazuo Wang , Kaisheng Liu , Bin Yang , Xianwen Yang , Yan Peng 1, Juan Liu 1, Zhe Ren 2 and Yonghong Liu 1,* 1 Key Laboratory of Marine Bio-Resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; E-Mails: xiupinglin@ (X.L.); xfzhou@ (X.Z.); wangfazuo@ (F.W.); bingo525@163.com (B.Y.); xwyang@ (X.Y.); py00_2006@126.com (Y.P.); ljuan2010@ (J.L.) 2 Biomedicine Research and Development Center of Jinan University, Guangzhou 510632, China; E-Mails: liukaisheng1987@163.com (K.L.); rz62@163.com (Z.R.) * Author to whom correspondence should be addressed; E-Mail: yonghongliu@; Tel.: +86-020-8902-3244; Fax: +86-020-8445-1672. Received: 28 November 2011; in revised form: 26 December 2011 / Accepted: 9 January 2012 / Published: 12 January 2012 Abstract: A new fungal strain, displaying strong toxic activity against brine shrimp larvae, was isolated from a deep sea sediment sample collected at a depth of 1300 m. The strain, designated as F00120, was identified as a member of the genus Penicillium on the basis of morphology