a review on mixing in microfluidics回顾在微流体的混合.pdfVIP

Micromachines 2010, 1, 82-111; doi:10.3390/mi1030082 OPEN ACCESS micromachines ISSN 2072-666X /journal/micromachines Review A Review on Mixing in Microfluidics Yong Kweon Suh * and Sangmo Kang Department of Mechanical Engineering, Dong-A University, 840 Hadan-dong, Saha-gu, Busan 604-714, Korea; E-Mail: kangsm@dau.ac.kr * Author to whom correspondence should be addressed; E-Mail: yksuh@dau.ac.kr; Tel.: +82-51-200-7648; Fax: +82-51-200-7656. Received: 28 July 2010; in revised form: 9 September 2010 / Accepted: 26 September 2010 / Published: 30 September 2010 Abstract: Small-scale mixing is of uttermost importance in bio- and chemical analyses using micro TAS (total analysis systems) or lab-on-chips. Many microfluidic applications involve chemical reactions where, most often, the fluid diffusivity is very low so that without the help of chaotic advection the reaction time can be extremely long. In this article, we will review various kinds of mixers developed for use in microfluidic devices. Our review starts by defining the terminology necessary to understand the fundamental concept of mixing and by introducing quantities for evaluating the mixing performance, such as mixing index and residence time. In particular, we will review the concept of chaotic advection and the mathematical terms, Poincare section and Lyapunov exponent. Since these concepts are developed from nonli