a role for dendritic translation of camkiiα mrna in olfactory plasticity树突的作用翻译嗅觉camkiiαmrna的可塑性.pdfVIP

A Role for Dendritic Translation of CaMKIIa mRNA in Olfactory Plasticity ´ 1,2 ´ ´ ` 3,4,5 1,2 1,2 1,2 Marie Neant-Fery , Eleonore Peres , Carole Nasrallah , Monica Kessner , Simona Gribaudo , 6 3,4,5 1,2 ´ 1,2,7 Charles Greer , Anne Didier , Alain Trembleau , Isabelle Caille * 1Team ‘‘Development and Plasticity of Neural Networks’’, UPMC Univ Paris 06, UMR Centre National de la Recherche Scientifique 7102, Paris, France, 2 CNRS, UMR 7102, Paris, France, 3 Lyon Neuroscience Research Center, Neuroplasticity and Neuropathology of Olfactory Perception Team, Univ Lyon 1, Lyon, France, 4 Institut National ´ ´ Scientifique d’Etudes et de Recherches Medicales (INSERM), UMR 1028, Lyon, France, 5 CNRS, UMR5292, Lyon, France, 6 Department of Neurosurgery, Yale University ´ School of Medicine, New Haven, Connecticut, United States of America, 7 University Paris Diderot, Sorbonne Paris Cite, Paris, France Abstract Local protein synthesis in dendrites contributes to the synaptic modifications underlying learning and memory. The mRNA encoding the a subunit of the calcium/calmodulin dependent Kinase II (CaMKIIa) is dendritically localized and locally translated. A role for CaMKIIa local translation in hippocampus-dependent memory has been demonstrated in mice with disrupted CaMKIIa dendritic translation, through deletion