原创力文档a single nucleotide polymorphism of the neuropeptide bw receptor-1 gene influences the evaluation of facial expressions神经肽bw的接收器1号基因的单核苷酸多态性影响面部表情的评价.pdfVIP
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a single nucleotide polymorphism of the neuropeptide bw receptor-1 gene influences the evaluation of facial expressions神经肽bw的接收器1号基因的单核苷酸多态性影响面部表情的评价
A Single Nucleotide Polymorphism of the Neuropeptide
B/W Receptor-1 Gene Influences the Evaluation of Facial
Expressions
1,2,3 1 1,4 1,2 5
Noriya Watanabe , Mari Wada , Yoko Irukayama-Tomobe , Yousuke Ogata , Natsuko Tsujino ,
5 5 5,6 1
Mika Suzuki , Naoki Furutani , Takeshi Sakurai *, Miyuki Yamamoto *
1 Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan, 2 Japan Society for the Promotion of Science, Tokyo, Japan, 3 Graduate School of
Engineering, Tamagawa University, Machida, Tokyo, Japan, 4 University of Tsukuba Center for Behavioral Molecular Genetics (FIRST Program), Tokyo, Japan, 5 Department
of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan, 6 Exploratory Research for Advanced
Technology Yanagisawa Orphan Receptor Project, Japan Science and Technology Agency, Tokyo, Japan
Abstract
Neuropeptide B/W receptor-1 (NPBWR1) is expressed in discrete brain regions in rodents and humans, with particularly
strong expression in the limbic system, including the central nucleus of the amygdala. Recently, Nagata-Kuroiwa et al.
reported that Npbwr12/ 2 mice showed changes in social behavior, suggesting that NPBWR1 plays important roles in the
emotional responses of social interactions. The human NPBWR1 gene has a single nucleotide polymorphism at nucleotide
404 (404A.T; SNP r. This polymorphism results in an amino acid change, Y135F. The results of an in vitro
experiment demonstrated
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