a submarine journey the pyrrole-imidazole alkaloidspyrrole-imidazole生物碱的海底之旅.pdfVIP

Mar. Drugs 2009, 7, 705-753; doi:10.3390/md7040705 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Review A Submarine Journey: The Pyrrole-Imidazole Alkaloids † 1 2 1 2 Barbara Forte , Beatrice Malgesini , Claudia Piutti , Francesca Quartieri , Alessandra Scolaro 1 and Gianluca Papeo 1,* 1 Department of Medicinal Chemistry, Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano, Milano, Italy; E-Mails: barbara.forte@ (B.F.); claudia.piutti@ (C.P.); alessandra.scolaro@ (A.S.) 2 Department of Chemical Core Technologies, Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano, Milano, Italy; E-Mails: beatrice.malgesini@ (B.M.); francesca.quartieri@ (F.Q.) † Dedicated to our colleague and friend Dr. Sergio Mantegani, in recognition of his merits in natural products chemistry, and in appreciation of his relentless endeavor to teach, advise and share his chemistry skills in our organization. * Author to whom correspondence should be addressed; E-Mail: gianluca.papeo@; Tel.: +39-0331-58-1537; Fax: +39-0331-58-1347. Received: 30 October 2009; in revised form: 20 November 2009 / Accepted: 26 November 2009 / Published: 27 November 2009 Abstract: In his most celebrated tale “The Picture of Dorian Gray”, Oscar Wilde stated that “those who go beneath the surface do so at their peril”. This sentence could be a prophetical warning for the practitioner who voluntarily challenges himself with trying to