activation of p2x7 receptor by atp plays an important role in regulating inflammatory responses during acute viral infectionp2x7受体的激活atp调节炎症反应中起着重要的作用在急性病毒性感染.pdfVIP
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activation of p2x7 receptor by atp plays an important role in regulating inflammatory responses during acute viral infectionp2x7受体的激活atp调节炎症反应中起着重要的作用在急性病毒性感染
Activation of P2X7 Receptor by ATP Plays an Important
Role in Regulating Inflammatory Responses during Acute
Viral Infection
1,3 2,4 1,4 1,5 6
Benjamin H. Lee , David M. Hwang , Nades Palaniyar , Sergio Grinstein , Dana J. Philpott ,
Jim Hu1,4*
1 Research Institute, The Hospital for Sick Children, Toronto, Canada, 2 Toronto General Hospital/University Health Network, Toronto, Canada, 3 The Institute of Medical
Science, University of Toronto, Toronto, Canada, 4 Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, Canada, 5 Department of
Biochemistry, University of Toronto, Toronto, Canada, 6 Department of Immunology, University of Toronto, Toronto, Canada
Abstract
Acute viral infection causes damages to the host due to uncontrolled viral replication but even replication deficient viral
vectors can induce systemic inflammatory responses. Indeed, overactive host innate immune responses to viral vectors have
led to devastating consequences. Macrophages are important innate immune cells that recognize viruses and induce
inflammatory responses at the early stage of infection. However, tissue resident macrophages are not easily activated by the
mere presence of virus suggesting that their activation requires additional signals from other cells in the tissue in order to
trigger inflammatory responses. Previously, we have shown that the cross-talk between epithelial cells and macrophages
generates synergistic inflammatory responses during adenoviral vector infection. Here, we investigated whether ATP is
involved in the activation of macrophages to induce inflammatory responses during an acute adenoviral infection. Using a
macrophage-epithelial
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