原创力文档agonistic and antagonistic roles for tnik and mink in non-canonical and canonical wnt signalling织和敌对角色tnik和貂在非规范和规范wnt信号.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
agonistic and antagonistic roles for tnik and mink in non-canonical and canonical wnt signalling织和敌对角色tnik和貂在非规范和规范wnt信号
Agonistic and Antagonistic Roles for TNIK and MINK in
Non-Canonical and Canonical Wnt Signalling
Alexander Mikryukov1,2,3¤, Tom Moss1,2,3*
´
1 Laboratory of Growth and Development, Cancer Research Centre, Laval University, Quebec City, Quebec, Canada, 2 Department of Molecular Biology, Medical
´
Biochemistry and Pathology, Laval University, Quebec City, Quebec, Canada, 3 Cancer Axis, Research Centre of the Quebec University Hospital Centre, Quebec City,
´
Quebec, Canada
Abstract
Wnt signalling is a key regulatory factor in animal development and homeostasis and plays an important role in the
establishment and progression of cancer. Wnt signals are predominantly transduced via the Frizzled family of serpentine
receptors to two distinct pathways, the canonical ß-catenin pathway and a non-canonical pathway controlling planar cell
polarity and convergent extension. Interference between these pathways is an important determinant of cellular and
phenotypic responses, but is poorly understood. Here we show that TNIK (Traf2 and Nck-interacting kinase) and MINK
(Misshapen/NIKs-related kinase) MAP4K signalling kinases are integral components of both canonical and non-canonical
pathways in Xenopus. xTNIK and xMINK interact and are proteolytically cleaved in vivo to generate Kinase domain
fragments that are active in signal transduction, and Citron-NIK-Homology (CNH) Domain fragments that are suppressive.
The catalytic activity of the Kinase domain fragments of both xTNIK and xMINK mediate non-canonical signalling. However,
while the Kinase domain fragments of xTNIK also me
您可能关注的文档
- activation of multiple apoptotic pathways in human nasopharyngeal carcinoma cells by the prenylated isoflavone, osajin激活多种凋亡通路在人类鼻咽癌细胞prenylated异黄酮,osajin.pdf
- activation of myocardial phosphoinositide-3-kinase p110α ameliorates cardiac dysfunction and improves survival in polymicrobial sepsis激活心肌phosphoinositide-3-kinase p110α改善心脏功能障碍,提高脓毒症生存幼童腹壁薄弱.pdf
- activation of human monocytes by live borrelia burgdorferi generates tlr2-dependent and -independent responses which include induction of ifn-β激活人类单核细胞的生活产生tlr2-dependent伯氏疏螺旋体和独立反应,包括ifn-β的感应.pdf
- activation of nk cells by an endocytosed receptor for soluble hla-g激活nk细胞的内源性可溶性hla-g受体.pdf
- activation of nf-κb in basolateral amygdala is required for memory reconsolidation in auditory fear conditioning需要激活的nf-κb基底外侧杏仁核在听觉记忆重塑恐惧条件反射.pdf
- activation of jnk triggers release of brd4 from mitotic chromosomes and mediates protection from drug-induced mitotic stress激活物触发释放brd4从药物引起的有丝分裂染色体有丝分裂和调节保护压力.pdf
- activation of myd88 signaling upon staphylococcal enterotoxin binding to mhc class ii molecules激活myd88信号在葡萄球菌肠毒素结合mhc ii级分子.pdf
- activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme激活p53的nutlin-3a人类多形性成胶质细胞瘤凋亡和细胞衰老.pdf
- activation of p2x7 receptor by atp plays an important role in regulating inflammatory responses during acute viral infectionp2x7受体的激活atp调节炎症反应中起着重要的作用在急性病毒性感染.pdf
- activation of pax7-positive cells in a non-contractile tissue contributes to regeneration of myogenic tissues in the electric fish s. macrurusnon-contractile组织有助于激活pax7-positive细胞再生的肌原性的组织美国macrurus电鱼.pdf
- air change rates and interzonal flows in residences, and the need for multi-zone models for exposure and health analyses在住宅换气率和层间流动,需要分域模型暴露和健康分析.pdf
- air conditioning systems from a 2nd law perspective空调系统从第二定律的角度.pdf
- aip4itch regulates notch receptor degradation in the absence of ligandaip4itch调节切口没有配体受体退化.pdf
- air gasification of agricultural waste in a fluidized bed gasifier hydrogen production performance空气气化流化床气化炉的农业废弃物制氢性能.pdf
- air manganese levels and chronic liver disease mortality in north carolina counties an ecological study空气锰水平和慢性肝脏疾病的死亡率在北卡罗莱纳县生态研究.pdf
- aid-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center b cellsaid-targeting hypermutation non-immunoglobulin基因并没有与接近在生发中心b细胞免疫球蛋白基因.pdf
- air pollution exposure—a trigger for myocardial infarction空气污染辐射引发心肌梗死.pdf
- agrobacterium tumefaciens-induced bacteraemia does not lead to reporter gene expression in mouse organs农杆菌属tumefaciens-induced菌血症不会导致记者基因表达在小鼠器官.pdf
- air pollution and cardiovascular health in mandi-gobindgarh, punjab, india - a pilot study空气污染与心血管健康mandi-gobindgarh,旁遮普,印度u2014u2014一个试点研究.pdf
- air quality and acute respiratory illness in biomass fuel using homes in bagamoyo, tanzania空气质量和急性呼吸道疾病在生物质燃料在巴哥莫约都使用房屋,坦桑尼亚.pdf
文档评论（0）