allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation过敏性哮喘患者显示不同脂质中介配置文件从健康控制基线和桦树花粉后挑衅.pdfVIP

Allergic Asthmatics Show Divergent Lipid Mediator Profiles from Healthy Controls Both at Baseline and following Birch Pollen Provocation ¨ 1 2 ¨ 3 4 4 Susanna L. Lundstrom , Jun Yang , Henrik J. Kallberg , Sarah Thunberg , Guro Gafvelin , Jesper Z. ¨ 1 ¨ 5 5 4 2 Haeggstrom , Reidar Gronneberg , Johan Grunewald , Marianne van Hage , Bruce D. Hammock , 5 ˚ 5 1 Anders Eklund , Asa M. Wheelock *, Craig E. Wheelock * 1 Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, 2 Department of Entomology and Cancer Center, University of California Davis, Davis, California, United States of America, 3 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 4 Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 5 Division of Respiratory Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden Abstract Background: Asthma is a respiratory tract disorder characterized by airway hyper-reactivity and chronic inflammation. Allergic asthma is associated with the production of allergen-specific IgE and expansion of allergen-specific T-cell populations. Progression of allergic inflammation is driven by T-helper type 2 (Th2) mediators and is associated with alter