原创力文档alterations in glutathione redox metabolism, oxidative stress, and mitochondrial function in the left ventricle of elderly zucker diabetic fatty rat heart改变谷胱甘肽氧化还原代谢、氧化应激和线粒体功能的左心室老年糖尿病脂肪zucker鼠的心.pdfVIP
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alterations in glutathione redox metabolism, oxidative stress, and mitochondrial function in the left ventricle of elderly zucker diabetic fatty rat heart改变谷胱甘肽氧化还原代谢、氧化应激和线粒体功能的左心室老年糖尿病脂肪zucker鼠的心
Int. J. Mol. Sci. 2012, 13, 16241-16254; doi:10.3390/ijms131216241
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Alterations in Glutathione Redox Metabolism, Oxidative Stress,
and Mitochondrial Function in the Left Ventricle of Elderly
Zucker Diabetic Fatty Rat Heart
Haider Raza 1,*, Annie John 1 and Frank C. Howarth 2
1 Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates
University, Al Ain, P.O. Box 17666, UAE; E-Mail: anniej@uaeu.ac.ae
2 Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates
University, Al Ain, P.O. Box 17666, UAE; E-Mail: chris.howarth@uaeu.ac.ae
* Author to whom correspondence should be addressed; E-Mail: h.raza@uaeu.ac.ae;
Tel.: +971-3-7137506; Fax: +971-3-7672033.
Received: 20 September 2012; in revised form: 31 October 2012 / Accepted: 19 November 2012 /
Published: 30 November 2012
Abstract: The Zucker diabetic fatty (ZDF) rat is a genetic model in which the homozygous
(FA/FA) male animals develop obesity and type 2 diabetes. Morbidity and mortality from
cardiovascular complications, due to increased oxidative stress and inflammatory signals,
are the hallmarks of type 2 diabetes. The precise molecular mechanism of contractile
dysfunction and disease progression remains to be clarified. Therefore, we have
investigated molecular and metabolic targets i
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