amerindian helicobacter pylori strains go extinct, as european strains expand their host range美洲印第安人的幽门螺杆菌菌株灭绝,因为欧洲株扩大宿主范围.pdfVIP

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amerindian helicobacter pylori strains go extinct, as european strains expand their host range美洲印第安人的幽门螺杆菌菌株灭绝,因为欧洲株扩大宿主范围.pdf

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amerindian helicobacter pylori strains go extinct, as european strains expand their host range美洲印第安人的幽门螺杆菌菌株灭绝,因为欧洲株扩大宿主范围

Amerindian Helicobacter pylori Strains Go Extinct, as European Strains Expand Their Host Range ´ 1 ´ 2 3 3 2 Maria G. Domınguez-Bello *, Maria E. Perez , Maria C. Bortolini , Francisco M. Salzano , Luis R. Pericchi , ´ 4, Bodo Linz5 Orlisbeth Zambrano-Guzman 1 Department of Biology, University of Puerto Rico, San Juan, Puerto Rico, United States of America, 2 Department of Mathematics, University of Puerto Rico, San Juan, Puerto Rico, United States of America, 3 Department of Genetics, Universidade Federal Rio Grande do Sul, Porto Alegre, Brazil, 4 Bilingual Intercultural Department, ¨ Universidad Pedagogica Experimental Libertador, Puerto Ayacucho, Venezuela, 5 Department of Molecular Biology, Max-Planck-Institut fur Infektionsbiologie, Berlin, Germany Abstract We studied the diversity of bacteria and host in the H. pylori-human model. The human indigenous bacterium H. pylori diverged along with humans, into African, European, Asian and Amerindian groups. Of these, Amerindians have the least genetic diversity. Since niche diversity widens the sets of resources for colonizing species, we predicted that the Amerindian H. pylori strains would be the least diverse. We analyzed the multilocus sequence (7 housekeeping genes) of 131 strains: 19 cultured from Africans, 36 from Spanish, 11 from Koreans, 43 from Amerindians and 22 from South American Mestizos. We found that all strains that had been cultured from Africans were African strains (hpAfrica1), all from Spanish were European