an abundant tissue macrophage population in the adult murine heart with a distinct alternatively-activated macrophage profile人口丰富组织巨噬细胞在成年小鼠心脏明显的替代性活化巨噬细胞.pdfVIP

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an abundant tissue macrophage population in the adult murine heart with a distinct alternatively-activated macrophage profile人口丰富组织巨噬细胞在成年小鼠心脏明显的替代性活化巨噬细胞.pdf

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an abundant tissue macrophage population in the adult murine heart with a distinct alternatively-activated macrophage profile人口丰富组织巨噬细胞在成年小鼠心脏明显的替代性活化巨噬细胞

An Abundant Tissue Macrophage Population in the Adult Murine Heart with a Distinct Alternatively-Activated Macrophage Profile 1,2 1 1 1 1 Alexander R. Pinto *, Rosa Paolicelli , Ekaterina Salimova , Janko Gospocic , Esfir Slonimsky , 1 2 1,2,3 Daniel Bilbao-Cortes , James W. Godwin , Nadia A. Rosenthal * 1 European Molecular Biology Laboratory (EMBL) Mouse Biology Unit, Monterotondo (Rome), Italy, 2 Australian Regenerative Medicine Institute (ARMI), Monash University, Clayton, Victoria, Australia, 3 Harefield Heart Science Centre, National Heart and Lung Institute, Imperial College London, London, United Kingdom Abstract Cardiac tissue macrophages (cTMs) are a previously uncharacterised cell type that we have identified and characterise here as an abundant GFP+ population within the adult Cx cr1GFP/+ knock-in mouse heart. They comprise the predominant 3 myeloid cell population in the myocardium, and are found throughout myocardial interstitial spaces interacting directly with capillary endothelial cells and cardiomyocytes. Flow cytometry-based immunophenotyping shows that cTMs exhibit canonical macrophage markers. Gene expression analysis shows that cTMs (CD45+ + + CD11b GFP ) are distinct from mononuclear CD45+ + + GFP/+