an improved synthesis of 7, 8-epoxy-1,3,11-cembratriene-15r(α), 16-diol, a cembranoid of marine origin with a potent cancer chemopreventive activity改进合成7,8-epoxy-1 3 11-cembratriene-15r(α),16-diol,cembranoid海相成因的一种强有力的癌症chemopreventive活动.pdfVIP

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an improved synthesis of 7, 8-epoxy-1,3,11-cembratriene-15r(α), 16-diol, a cembranoid of marine origin with a potent cancer chemopreventive activity改进合成7,8-epoxy-1 3 11-cembratriene-15r(α),16-diol,cembranoid海相成因的一种强有力的癌症chemopreventive活动.pdf

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an improved synthesis of 7, 8-epoxy-1,3,11-cembratriene-15r(α), 16-diol, a cembranoid of marine origin with a potent cancer chemopreventive activity改进合成7,8-epoxy-1 3 11-cembratriene-15r(α),16-diol,cembranoid海相成因的一种强有力的癌症chemopreventive活动

Mar. Drugs 2004, 2, 1-7 Marine Drugs ISSN 1660-3397 /marinedrugs/ An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene- 15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity Hesham Fahmy 1, Sherief I. Khalifa 2, Takao Konoshima 3 and Jordan K. Zjawiony 1,* 1 Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677-1848, U.S.A. Tel. (662) 915-7290, Fax (662) 915-6975, E-mail: heshamfahmy@ 2 Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. Tel +20 64-341136, Fax: + 20 64-355741, E-mail: jkhalifa_99@ 3 Laboratory of Pharmaceutical Sciences of Natural Resources, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan, Tel. +81 75-5954645, Fax +81 75-5832230, E-mail: konosima@mb.kyoto-phu.ac.jp * Author to whom correspondence should be addressed; E-mail: jordan@ Received: 29 October 2003 / Accepted: 20 November 2003 / Published: 25 February 2004 Abstract: An effective method for the synthesis of 7,8-epoxy-1,3,11-cembratriene- 15R(α),16-diol and its in vitro Epstein-Barr Virus Early Antigen (EBV-EA) Activation Chemopreventive Assay are reported. This semisynthetic product is a new cembranoid with a potent tumor inhibitory activity that is expected to be a lead compound for a new class of chemopreventive agents of marine origin. Keywords: cancer chemoprevention, cembranoids, sarcophine, sarcophytol A, EBV-EA activation. Mar. Drugs 2004, 2