antiprotozoal activities of organic extracts from french marine seaweeds法国海洋海藻antiprotozoal活动的有机提取物.pdfVIP

Mar. Drugs 2011, 9, 922-933; doi:10.3390/md9060922 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Antiprotozoal Activities of Organic Extracts from French Marine Seaweeds Catherine Vonthron-Sénécheau 1,2,*, Marcel Kaiser 3,4, Isabelle Devambez 2, Antoine Vastel 2, 2 2 Isabelle Mussio and Anne-Marie Rusig 1 Pharmacognosie et Molécules Naturelles Bio-actives, Laboratoire d’Innovation Thérapeutique UMR CNRS 7200, Faculté de Pharmacie, Université de Strasbourg, 74 route du Rhin, 67401 Illkirch cedex, France 2 Physiologie et Ecophysiologie des Mollusques Marins, UMR M IFREMER 100, Institut de Biologie Fondamentale et Appliquée (IBFA), Université de Caen Basse-Normandie, 14032 Caen cedex, France; E-Mails: devambez@unicaen.fr (I.D.); vastarel35@hotmail.fr (A.V.); isabelle.mussio@unicaen.fr (I.M.); anne-marie.rusig@unicaen.fr (A.-M.R.) 3 Swiss Tropical and Public Health Institution, Socinstrasse 57, 4002 Basel, Switzerland; E-Mail: Marcel.Kaiser@unibas.ch 4 University of Basel, Petersplatz 1, 4003 Basel, Switzerland * Author to whom correspondence should be addressed; E-Mail: vonthron@unistra.fr; Tel.: +33-368-854-242; Fax: +33-368-854-311. Received: 6 April 2011; in revised form: 13 May 2011 / Accepted: 23 May 2011 / Published: 25 May 2011 Abstract: Marine macrophytes contain a variety of biologically active compounds, some reported to have antiprotozoal activity in vitro. As a part of a screening program to search for new natural antiprotozoals, we screened hy