serpina1 piz and pis heterozygotes and lung function decline in the sapaldia cohortserpina1这款和π杂合子和sapaldia组肺功能下降.pdfVIP

SERPINA1 PiZ and PiS Heterozygotes and Lung Function Decline in the SAPALDIA Cohort 1,2 3 1,2 4 4 Gian-Andri Thun , Ilaria Ferrarotti , Medea Imboden , Thierry Rochat , Margaret Gerbase , 5 4 1,2 3 Florian Kronenberg , Pierre-Olivier Bridevaux , Elisabeth Zemp , Michele Zorzetto , 3 6 3 1,2 Stefania Ottaviani , Erich W. Russi , Maurizio Luisetti , Nicole M. Probst-Hensch * 1 Swiss Tropical and Public Health Institute, Basel, Switzerland, 2 University of Basel, Basel, Switzerland, 3 Center for Diagnosis of Inherited Alpha1-antitrypsin Deficiency, Institute for Respiratory Disease, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, Italy, 4 Division of Pulmonary Medicine, University Hospital of Geneva, Geneva, Switzerland, 5 Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria, 6 Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland Abstract Background: Severe alpha1-antitrypsin (AAT) deficiency is a strong risk factor for COPD. But the impact of gene variants resulting in mild or intermediate AAT deficiency on the longitudinal course of respiratory health remains controversial. There is indication from experimental studies that pro-inflammatory agents like cigarette smoke can interact with these variants and thus increase the risk o