原创力文档secretion of hepatitis c virus envelope glycoproteins depends on assembly of apolipoprotein b positive lipoproteins分泌的丙型肝炎病毒包膜糖蛋白取决于组装载脂蛋白b的积极的脂蛋白.pdfVIP
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secretion of hepatitis c virus envelope glycoproteins depends on assembly of apolipoprotein b positive lipoproteins分泌的丙型肝炎病毒包膜糖蛋白取决于组装载脂蛋白b的积极的脂蛋白
Secretion of Hepatitis C Virus Envelope Glycoproteins
Depends on Assembly of Apolipoprotein B Positive
Lipoproteins
Vinca Icard1,2,3,4., Olivier Diaz1,2,3., Caroline Scholtes1,2,3,4, Laure Perrin-Cocon1,2,3, Christophe
` 1,2,3,4 5 6 1,2,3,4 ´ 1,2,3,4
Ramiere , Ralf Bartenschlager , Francois Penin , Vincent Lotteau , Patrice Andre *
´ ´
1 Universite de Lyon, Lyon, France, 2 Inserm, U851, Lyon, France, 3 Universite de Lyon1, IFR128 BioSciences Lyon-Gerland, Lyon, France, 4 Hospices Civils de Lyon,
Laboratoire de Virologie Nord, Lyon, France, 5 Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany, 6 CNRS, UMR 5086, Institut de Biologie et
´
Chimie des Proteines, Lyon, France
Abstract
The density of circulating hepatitis C virus (HCV) particles in the blood of chronically infected patients is very
heterogeneous. The very low density of some particles has been attributed to an association of the virus with
apolipoprotein B (apoB) positive and triglyceride rich lipoproteins (TRL) likely resulting in hybrid lipoproteins known as lipo-
viro-particles (LVP) containing the viral envelope glycoproteins E1 and E2, capsid and viral RNA. The specific infectivity of
these particles has been shown to be higher than the infectivity of particles of higher density. The nature of the association
of HCV particles with lipoproteins remains elusive and the role of apolipoproteins in the synthesis and assembly of the viral
particles is unknown. The human intestinal Caco-2 cell line differentia
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