routine habitat change a source of unrecognized transient alteration of intestinal microbiota in laboratory mice常规栖息地变化的来源识别瞬态改变肠道微生物群在实验室老鼠.pdfVIP
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routine habitat change a source of unrecognized transient alteration of intestinal microbiota in laboratory mice常规栖息地变化的来源识别瞬态改变肠道微生物群在实验室老鼠
Routine Habitat Change: A Source of Unrecognized
Transient Alteration of Intestinal Microbiota in
Laboratory Mice
1,2 3,4 2 2 5
Betty W. Ma , Nicholas A. Bokulich , Patricia A. Castillo , Anchasa Kananurak , Mark A. Underwood ,
3,4 2
David A. Mills , Charles L. Bevins *
1 Center for Laboratory Animal Science, School of Veterinary Medicine - Residency Program in Laboratory Animal Medicine, University of California Davis, Davis, California,
United States of America, 2 Department of Microbiology and Immunology, School of Medicine, University of California Davis, Davis, California, United States of America,
3 Department of Food Science and Technology, University of California Davis, Davis, California, United States of America, 4 Department of Viticulture and Enology,
University of California Davis, Davis, California, United States of America, 5 Department of Pediatrics, School of Medicine, University of California Davis, Sacramento,
California, United States of America
Abstract
The mammalian intestine harbors a vast, complex and dynamic microbial population, which has profound effects on host
nutrition, intestinal function and immune response, as well as influence on physiology outside of the alimentary tract.
Imbalance in the composition of the dense colonizing bacterial population can increase susceptibility to various acute and
chronic diseases. Valuable insights on the association of the microbiota with disease critically depend on investigation of
mouse models. Like in humans, the microbial community in the mouse intestine is relatively stable and resilient, yet can be
influenced by environmental factors. A
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