risk of hormone escape in a human prostate cancer model depends on therapy modalities and can be reduced by tyrosine kinase inhibitors激素逃脱人类前列腺癌的风险模型取决于治疗模式,可以减少酪氨酸激酶抑制剂.pdfVIP
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risk of hormone escape in a human prostate cancer model depends on therapy modalities and can be reduced by tyrosine kinase inhibitors激素逃脱人类前列腺癌的风险模型取决于治疗模式,可以减少酪氨酸激酶抑制剂
Risk of Hormone Escape in a Human Prostate Cancer
Model Depends on Therapy Modalities and Can Be
Reduced by Tyrosine Kinase Inhibitors
1 ´ 2 ´ 1,3,4,5 ´ 6 7
Charlotte Guyader , Jocelyn Ceraline , Eleonore Gravier , Aurelie Morin , Sandrine Michel ,
2 8 6 2 1
Eva Erdmann , Gonzague de Pinieux , Florence Cabon , Jean-Pierre Bergerat , Marie-France Poupon ,
´ 9,10*
Stephane Oudard
´
1Translational Research Department, Institut Curie, Paris, France, 2 Signaling and Prostate Cancer Group, Universite de Strasbourg, Strasbourg, France, 3 Biostatistics
Department, Institut Curie, Paris, France, 4 U900, INSERM, Paris, France, 5 Ecole des Mines de Paris, ParisTech, Fontainebleau, France, 6 FRE2944, CNRS, Villejuif, France,
´ ˆ
7 Biomarker Research and Validation Department, BioMerieux, Marcy l’Etoile, France, 8 Anatomie et Cytologie Pathologiques, Hopital Trousseau, Tours, France, 9 Medical
ˆ ´ ´ ´
Oncology, Hopital Europeen Georges Pompidou, Paris, France, 10 Universite Paris V Rene Descartes, Paris, France
Abstract
Almost all prostate cancers respond to androgen deprivation treatment but many recur. We postulated that risk of hormone
escape -frequency and delay- are influenced by hormone therapy modalities. More, hormone thera
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